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How Long Should I Use Chlorhexidine Mouthwash?

Updated: Nov 15, 2023

On average, chlorhexidine mouthwash (CHX) should be used for 2 weeks at most unless otherwise directed by your dentist.

chlorhexidine gluconate oral rinse

The two major reasons for the 2 weeks time limit are due to the maximum dosage size and potential adverse effects from long term use. While this medicated mouth rinse isn't harmful per say, it does come with some undesirable side effects.

Maximum dosage size

On average, most dentists licensed in the US will tell their patients that they should use chlorhexidine mouthwash for two weeks at most. This recommendation is what we were taught in dental school and consequently what our colleagues all abide to.

Perhaps it's not so obvious but the maximum dosage size for a prescription bottle of chlorhexidine gluconate oral rinse is 473 mL. The significance of that number is that when you use the CHX mouthwash as directed, it gives a maximum of two weeks of use!

Chlorhexidine standard bottle size 473 ml
Standard bottle size 473 mL
  1. Fill the cap to the "fill line" which is 15 mL.

  2. Swish around in mouth for 30 seconds undiluted.

  3. Spit out and do NOT rinse with water immediately afterwards.

  4. Use twice a day (after breakfast and before bed).

Chlorhexidine mouthwash - fill line on bottle cap
15 mL cap fill line

Evidence of 2 weeks maximum use

Now, let me do some math to prove to you that you only get 2 weeks of use.

  • Standard size bottle of CHX = 473 mL

  • Use twice a day with 15 mL each time = 30 mL total per day

  • 473/30 = ~15 days of use

In summary, a full bottle of chlorhexidine oral rinse will last you approximately 2 weeks. Therefore, if you were prescribed a bottle of CHX, you'd only be able to use it for 2 weeks at most because of the dosage size and bottle size limitation.

The only way to use chlorhexidine for longer than 2 weeks is if you have a prescription refill.

Chlorhexidine adverse effects

One of the main hesitations in using chlorhexidine gluconate oral rinse long term is due to it's staining potential. It can cause brown discolorations to your teeth, tongue, and dental fillings.

Even if you're not actively whitening your teeth at the moment, nobody wants their teeth to purposely become more yellow in color. The risk of teeth staining from chlorhexidine use only increases the longer that you use it.

Therefore in order to minimize staining, you should only use it for a short period of time.

Staining mechanism

Chlorhexidine mouthwash does not directly stain your teeth but it makes them more prone to staining. Research has shown that after rinsing with CHX, teeth become more strongly attracted to colored dyes.

brown discoloration on teeth
brown discoloration on teeth

That means if you eat or drink stainings foods, they will become more potent at discoloring your enamel than they normally would.

The cause for this strong attraction has to do with the fact that CHX is positively charged while stain molecules tend to be negatively charged. As we all know, opposites attract!

How to remove the stains

Fortunately, chlorhexidine stains can be removed by having your teeth professionally cleaned and by using whitening products. Yes, even the CHX stains on your tongue can be removed as well.

Chlorhexidine label - what to expect
Label - What to expect

The instructions on the label do say that good oral hygiene can help minimize the discolorations. That means you should be extra diligent while you're using this rinse.

Is it safe to use?

CHX mouthwash is relatively safe to use due to its poor absorption across membranes so its plasma levels are typically undetectable. Most of it is eliminated through feces (~90%) and less than 1% is excreted through urine.

In other words, even if some of it was ingested most of it would simply pass through your gastrointestinal tract. Most of CHX would just get pooped out without much of it being absorbed into your bloodstream.

Since our bodies can't really process and absorb it, that makes chlorhexidine relatively safe to use. However, you do have to be cautious in that while the CHX is poorly absorbed, there are other ingredients which may induce side effects such as the 11.6% alcohol content.

Alcohol content

Due to the alcohol content in CHX, if you accidentally ingest it, you may experience nausea and vomiting. Overall you'll get symptoms similar to inebriation. These side effects are nearly identical to if you swallowed one of the alcohol based essential oil mouthwashes like Listerine.

One of the reasons as to why the CHX oral rinse isn't recommended in those age 18 and under is partly due to the alcohol. Unless specified by your doctor, please keep it out of reach for those who are underaged.

Long term chlorhexidine use

Chlorhexidine gluconate oral rinse is mostly used for short durations of time such as 2 weeks. In the UK, it is licensed for 30 days of maximum use.

Reasons for short term use:

  • Adverse cosmetic effects such as staining.

  • It is an adjunctive treatment and not the primary one.

  • Since it is an antimicrobial rinse, it can induce antibiotic resistance for bacteria.

Due to all of the reasons above, it is not recommended to use chlorhexidine long term. However, there are always exceptions.


There are certain conditions which may require more frequent use of chlorhexidine oral rinse. When we say frequent, we mean that you may get a prescription for it more than once per year but you're still not using it every day. Therefore you're just using it more than the average person but still not as an everyday mouth rinse.

Conditions which may require more frequent CHX use:

  • Severe periodontal disease

  • Mouth full of implants

Typically it would have to be extenuating circumstances for your dentist to even consider this as an option. After all there are a lot of other great mouthwashes out there that don't require a prescription and they come with less adverse effects.

The Verdict

Chlorhexidine mouthwash should only be used for as long as 2 weeks because the size of the bottle only permits that many uses. Aside from that, most people really don't want to use this medicated oral rinse long term due to its adverse cosmetic effects.

However, if you were directed by your dentist to use it for longer than 2 weeks, you may do so. If this is your case then you most likely have an extenuating circumstance.

Nonetheless, the most common reason to be prescribed it is after a deep teeth cleaning and you really only need to use it for 2 weeks!



David Chen 200 x 200.jpg

About the author: Dr David Chen, DDS

Hello, I'm Dr Chen and I'm an actively practicing dentist in Long Island City, NY. I graduated from Columbia University College of Dental Medicine in 2016 but prior to going to dental school I was already working in the dental field. It's been more than a decade since I first got to know dentistry and let me tell you, time flies by quickly. Since then I've developed a fondness for writing, which is how this all got started!

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Medical Disclaimer:

This blog is purely meant for information purposes and should not be used as medical advice. Each situation in your mouth is unique and complex. It is not possible to give advice nor diagnose any oral conditions based on text nor virtual consultations. The best thing to do is to go in person to see your dentist for an examination and consultation so that you can receive the best care possible.

The purpose of all of this oral health information is to encourage you to see your dentist and to inform you of what you may expect during your visit. Due to the unfortunate nature of dentistry, there isn't really any true home remedies that will get rid of dental problems. Roughly 99.99% of them require in-person intervention by a healthcare professional.

Hint: That is the reason why you can't eliminate seeing dentists in your life!

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